Unlocking RNAi to empower
a new era of crop protection

Our Agrisome platform combines Nobel Prize-winning RNA interference technology with next-gen proteomics for multiple modes of action against insects, weeds and other pests

A breakthrough platform for precision agriculture – to better protect harvests, humans, and our planet

Trillium’s innovative crop protection platform overcomes critical challenges that have blocked other RNAi agtech from achieving sustained success. Our technology – known as Agrisomes – is comprised of exosome-like biologicals, with a nanoparticle core of single-stranded RNA surrounded by proteins, lipids, or virus-like particles.

The core is a novel ssRNAi trigger with several advantages over dsRNA agtech, while the protein shell provides protection through uptake and delivery – as well as additional modes of action in crop protection. These naturally derived, “programmable” nanoparticles can be composed in a near-endless variety to improve precision, delivery, and efficacy against insects, weeds, fungi, and other destructive organisms.

“I am committed to helping global agriculture become more sustainable and productive. Trillium Ag has established a unique platform that could help fully realize the undelivered promise of RNAi as a crop protection category. I’m excited to work with Trillium to help bring this promise to fruition.”

NEAL GUTTERSON, Ph.D.

Director, Trillium Ag
Former Chief Technology Officer, Dupont (now Corteva Agriscience)

NEWS & UPDATES

In the News: CEO Todd Hauser discusses the opportunities for RNAi agtech with AgroPages’ Grace Yuan – check out the article…

We’re solving for critical challenges to RNAi in agriculture

Multiple modes of action help Agrisomes overcome key hurdles that have blocked dsRNA-based RNAi from achieving success:

COLEOPTERA

  • Rapidly acquired dsRNA-resistance within few seasons of field application
HEMIPTERA

  • Highly resistant to oral uptake of RNA
  • Degradation during oral uptake
  • Digestive acidic pH
  • Sucking/piercing feeding makes topicals difficult
LEPIDOPTERA

  • Highly resistant to oral uptake of RNA
  • Degradation during oral uptake
  • Digestive alkaline pH
  • Gut protected by membrane barrier
  • Cells entrap and degrade RNA