Someday all pesticides will
Trillium Ag is leading the way
Trillium pioneers new biological platforms to create smarter, more sustainable crop protection – high-precision, high-performance defenses against today’s biggest crop threats.
OUR INNOVATION PLATFORM
We believe farmers shouldn’t need to choose between strengthening yields and safeguarding biodiversity. Inspired by nature and designed with AI, our Agrisome platform has unlocked the full promise of RNA interference (RNAi) as a more effective and sustainable way to fight harmful insects, weeds, fungi, and other pests. Today, we’re using it to help companies build a new class of field-ready bio-protectants.
01
Novel RNAi Trigger
At its core, Agrisome technology exploits RNAi – a natural method of cellular protection – to precisely target and kill harmful pest species. Distinct from traditional double-stranded technology that been problematic for ag uses, our single-stranded design has overcome those roadblocks and demonstrated higher efficacy in crop protection.
02
Programmable Nanoparticle
Multiple triggers combine in a nanostructure that can be ‘programmed’ to bind with a unique set of proteins for each target species or class. This protein shell improves stability, targeting, delivery, uptake, and potency – and adds other modes of action to its RNAi core.
03
Engineered Exosomes
These nanoparticles can also be packaged inside nature’s own nano-delivery system to add a second, biologically native layer of targeting and uptake. This enables tunable tissue and species specificity, gives protection through challenging environments (e.g., insect gut), and creates a modular path to higher potency and more consistent field performance.
04
Field-Ready Crystals
Nanoparticles can be locked (even within exosomes) in natural crystals to provide long-term protection and ‘barn-safe’ stability. Seed-trait compatible, crystals are ‘programmable’ for just-in-time release of their Agrisome cargo – while simplifying production and application.
05
AI-Driven Toolstack
Our proprietary software accelerates sequence design and particle composition, optimizing performance for each target pest and use case. Other tools streamline bioproduction, formulation, and screening – moving you faster from early designs to field-relevant candidates.
06
nPlanta
Bioproduction System
Our nPlanta cell-free TX/TL system makes it fast and easy for commercial partners to use our Agrisome technology, providing streamlined scalability from R&D to greenhouse trials.
Trillium unlocks the full promise of RNAi in agriculture
+ MORE EFFECTIVE
Novel design hits the target pest with precision, reducing collateral impact on beneficial organisms and supporting stewardship goals.
+ GREATER SPECIFICITY
Novel design hits the target pest with precision, reducing collateral impact on beneficial organisms and supporting stewardship goals.
+ FARM-READY STABILITY
Protective architectures and crystal formats help maintain activity through storage, handling, and harsh field conditions—supporting consistent performance where it matters.
+ MULTI-MODE ADVANTAGE
Beyond RNAi, the platform can add complementary modes of action via protein-shell composition and formulation—supporting stronger control and resistance management strategies.
+ ADAPTIVE, PROGRAMMABLE DESIGN
Tune sequence + particle composition + shell features to match different pests, crops, geographies, and product profiles without reinventing the platform each time.
+ BROAD, DURABLE IP PROTECTION
A deep patent portfolio—issued across key global market regions—covers the core RNAi designs, delivery architectures, stabilization formats, and enabling bioproduction, supporting freedom to operate and long-term defensibility across major crop-protection markets.
+ PARTNER ADOPTION SCALABILITY
A suite of AI-assisted tools and rapid bioproduction (nPlanta) support accelerates innovation and efficient scale-up from R&D supply through greenhouse trials and beyond – reducing operational friction for commercial teams.
Trillium Ag collaborates with a growing list of global crop protection companies to accelerate biopesticide innovation, development, and commercialization. If you’re exploring new approaches to critical challenges in agriculture, or striving to improve outcomes for your customers, we’re interested in working with you.
Full access for accelerated innovation across products and categories
Work with Trillium on specific programs to feed your development pipeline
License-ready POCs across lepidoptera, colepotera and hemiptera targets
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Learn more about how we can help
Let’s discuss your toughest challenges – or your biggest ambitions
